Document 0723
 DOCN  M94A0723
 TI    Modelling the HIV-1 infection cycle.
 DT    9412
 AU    Deacon N; McPhee D; Newnham J; Linger H; AIDS Molecular Biology Unit,
       Monash University.
 SO    Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:112 (poster no. 73).
       Unique Identifier : AIDSLINE ASHM5/94348932
 AB    We have developed a computational tool for biological research to study
       the replication strategy of the human immunodeficiency virus. This model
       incorporates a formal model using Petri Nets and scientific citations.
       In the development of the formal model we have uncovered some facets of
       the replication strategy that warrant further investigation due to the
       incompleteness of current knowledge. A detailed understanding of the
       replication strategy allows better definition of steps that might be
       amenable to novel antiviral development. Modelling this strategy on the
       computer facilitates formulating and testing hypotheses at a theoretical
       level and organising the burgeoning HIV literature within the structure
       of this easily interpreted model. Application of this to modelling roles
       for the HIV auxiliary proteins revealed details of Tat, Rev and Nef
       functions yet to be resolved.
 DE    *Computer Simulation  Gene Expression Regulation, Viral/PHYSIOLOGY
       Genes, nef/GENETICS  Genes, rev/GENETICS  Genes, tat/GENETICS  Human
       HIV Infections/*MICROBIOLOGY  HIV-1/GENETICS/*PHYSIOLOGY  Models,
       Genetic  Virus Replication/GENETICS/*PHYSIOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).